Colony Stimulating Factors
Introduction
Colony Stimulating Factors (CSFs) are a group of glycoproteins that regulate the production, differentiation, and function of blood cells, particularly white blood cells (WBCs), in the bone marrow. These naturally occurring or recombinant cytokines stimulate the bone marrow to produce granulocytes, macrophages, and other immune cells, enhancing the body’s ability to fight infections and recover from bone marrow suppression.
CSFs are widely used in oncology, hematology, and immunology to manage conditions such as neutropenia, which often results from chemotherapy, bone marrow transplantation, or congenital disorders.
Types of Colony Stimulating Factors
1. Granulocyte Colony Stimulating Factor (G-CSF)
Stimulates production of neutrophils.

